盛苗苗 副教授 硕士生导师
E-mail:shengmm@kust.edu.cn
教育经历
(1) 2009-09 至 2014-07, 北京协和威尼斯wns8885556,基础学院, 生物化学与分子生物学, 博士
(2) 2005-09 至 2009-07, 中央民族大学, 生物科学, 学士
工作经历
(1) 2016-11 至 今, 公司, 威尼斯wns8885556, 副教授
(2) 2014-07 至 2016-10, 公司, 威尼斯wns8885556, 讲师
研究方向
乳腺癌致病机制
科研基金
(1)云南省“兴滇英才支持计划”-青年拔尖项目,2021-01至2025-12, 50万元,在研,主持
(2)云南省科学技术厅, 基础研究专项, 202101AT070071, LINC01234调控I型干扰素信号通路促进三阴性乳腺癌增殖侵袭的分子机制研究, 2021-04 至 2024-03, 10万元, 在研, 主持
(3)国家自然科学基金地区项目,81560451,PIK3CA基因E545A和S553fs*7双位高频突变在乳腺癌中的作用机制及其与预后的关联分析,2016-01至2019-12,44.4万元,结题,主持
(4)公司人培项目,KKSY201560001,PIK3CA基因突变与乳腺癌预后的相关性分析,2015-05至2018-05,5万元,结题,主持
荣誉奖励
(1)荣获2022年公司“优秀教师”称号,2022.09
(2)荣获2019-2020学年安瑞“优秀教师奖”,2020.12
(3)荣获第三届云南省高校教师教学大赛一等奖,2019.12
(4)荣获红云园丁优秀教师奖,2019.12
(5)荣获公司2017-2018学年课堂教学比赛一等奖,2018.08
代表性论文
1) Zheng L#, He J#, Li M, Yuan H, Li H, Hu F, Chen L, Tang W*, Sheng M*. Clinical significance and mechanism of long noncoding RNA HAGLROS in triple negative breast cancer. Pathology-Research and Practice. 2022; 231:153810.
2) Bi M#, Zheng L#, Chen L, He J, Yuan C, Ma P, Zhao Y, Hu F, Tang W*, Sheng M*. ln RNA LINC01234 promotes triple-negative breast cancer progression through regulating the miR-429/SYNJ1 axis. Am J Transl Res. 2021; 13(10):11399-11412.
3) Zhao Y, Tang W, Sun L, Xiong D, Sheng M*, Luo Y*. The effects of PIK3CA and TP53 on prognosis in patients with Triple-negative breast cancer (TNBC): a single institution’s long-term follow-up (6 years). European Journal of Gynaecological Oncology. 2021, 42(6): 1320-1325.
4) Zhao Y, Sheng M, Zheng L, Xiong D, Yang K*, Luo Y*. Application of circulating tumor DNA in breast cancer. The breast journal. 2020, 26(9): 1797-1800.
5) Hu F, Chen L, Bi MY, Zheng L, He JX, Huang YZ, Zhang Y, Zhang XL, Guo Q, Luo Y, Tang WR, Sheng MM*. Potential of RASSF1A promoter methylation as a biomarker for colorectal cancer: Meta-analysis and TCGA analysis. Pathology, research and practice. 2020; 216:153009.
6) Dai W#, He J#, Zheng L, Bi M, Hu F, Chen M, Niu H, Yang J, Luo Y, Tang W, Sheng M*. miR-148b-3p, miR-190b, and miR-429 Regulate Cell Progression and Act as Potential Biomarkers for Breast Cancer. Journal of breast cancer. 2019; 22:219-36.
7) Wang R#, Yang Y#, Sheng M#, Bu D#, Huang F, Liu X, Zhou C, Dai C, Sun B, Zhu J, Qiao Y, Yao Y, Zhu H, Lu L, Pan H, Feng M, Deng K, Xing B, Lian W, Zhao Y*, Jiang C*. Phenotype-Genotype Association Analysis of ACTH-Secreting Pituitary Adenoma and Its Molecular Link to Patient Osteoporosis. International journal of molecular sciences. 2016; 29;17(10):1654.
8) Wang F, Li S, Zhao Y, Yang K, Chen M, Niu H, Yang J, Luo Y, Tang W*, Sheng M*. Predictive role of the overexpression for CXCR4, C-Met, and VEGF-C among breast cancer patients: A meta-analysis. Breast. 2016; 28:45-53.
9) Sheng M*, Zhao Y, Wang F, Li S, Wang X, Shou T, Luo Y, Tang W*. Targeted drugs for unselected patients with advanced non-small-cell lung cancer: a network meta-analysis. Journal of thoracic disease. 2016; 8:98-115.
10)Sheng M*, Wang F, Zhao Y, Li S, Wang X, Shou T, Luo Y, Tang W*. Comparison of clinical outcomes of patients with non-small-cell lung cancer harbouring epidermal growth factor receptor exon 19 or exon 21 mutations after tyrosine kinase inhibitors treatment: a meta-analysis. European journal of clinical pharmacology. 2016; 72:1-11.
11) Ju X#, Yan Y#, Liu Q, Li N, Sheng M, Zhang L, Li X, Liang Z, Huang F, Liu K, Zhao Y, Zhang Y, Zou Z, Du J, Zhong Y, Zhou H, Yang P, Lu H, Tian M, Li D, Zhang J, Jin N*, Jiang C*. Neuraminidase of Influenza A Virus Binds Lysosome-Associated Membrane Proteins Directly and Induces Lysosome Rupture. Journal of virology. 2015; 89:10347-58.
12) Zhong Y, Xu J, Li T, Yu X, Sheng M. Potential clinical treatment for Ebola pandemic. Science China Life sciences. 2014; 57:982-4.
13) Yang Y#, Sheng M#, Huang F, Bu D, Liu X, Yao Y, Dai C, Sun B, Zhu J, Jiao Y, Wei Z, Zhu H, Lu L, Zhao Y, Jiang C*, Wang R*. Downregulation of Insulin-like growth factor binding protein 6 is associated with ACTH-secreting pituitary adenoma growth. Pituitary. 2014; 17(6):505-13.
14) Sheng M#, Zhong Y#, Chen Y, Du J, Ju X, Zhao C, Zhang G, Zhang L, Liu K, Yang N, Xie P, Li D, Zhang MQ*, Jiang C*. Hsa-miR-1246, hsa-miR-320a and hsa-miR-196b-5p inhibitors can reduce the cytotoxicity of Ebola virus glycoprotein in vitro. Science China Life sciences. 2014; 57:959-72.
15) Huang F#, Guo J#, Zou Z#, Liu J#, Cao B#, Zhang S#, Li H, Wang W, Sheng M, Liu S, Pan J, Bao C, Zeng M, Xiao H, Qian G, Hu X, Chen Y, Zhao Y, Liu Q, Zhou H, Zhu J, Gao H, Yang S, Liu X, Zheng S, Yang J, Diao H, Cao H, Wu Y, Zhao M, Tan S, Guo D, Zhao X, Ye Y, Wu W, Xu Y, Penninger JM, Li D, Gao GF*, Jiang C*, Li L*. Angiotensin II plasma levels are linked to disease severity and predict fatal outcomes in H7N9-infected patients. Nature communications. 2014; 5:3595.
16) 盛苗苗;罗瑛;周小龙;唐文如;王芳;赵月光;李珊珊。一种乳腺癌PIK3CA突变基因及其应用。专利号:ZL 2015 1 0675152.6 授权公告日:2018.08.31
17) 盛苗苗;罗瑛;唐文如;张继虹;贾舒婷;吴晓明;刘静;周若宇;旦菊花。用于检测微量组织中EGFR基因突变的引物组合及其应用。专利号:ZL 2016 1 0417807.4 授权公告日:2019.11.08
18) 盛苗苗;李珊珊;罗瑛;唐文如;王芳;赵月光;张继虹;贾舒婷;吴晓明;刘静;周若宇;旦菊花。用于检测微量组织中KRAS基因突变的引物组合及其应用。专利号:ZL 2016 1 0417802.1 授权公告日:2019.11.08
19) 盛苗苗;罗瑛;唐文如;李珊珊;王芳;赵月光;张继虹;贾舒婷;吴晓明;刘静;周若宇;旦菊花。用于检测微量组织中P53基因突变的引物组合及其应用。专利号:ZL 2016 1 0418005.5 授权公告日:2019.11.08
20) 盛苗苗;罗瑛;唐文如;李珊珊;王芳;赵月光;张继虹;贾舒婷;吴晓明;刘静;周若宇;旦菊花。用于检测微量组织中PIK3CA基因突变的引物组合及其应用。 专利号:ZL 2016 1 0418048.3 授权公告日:2019.11.08
21) 盛苗苗;罗瑛;唐文如;李珊珊;王芳;赵月光;张继虹;贾舒婷;吴晓明;刘静;周若宇;旦菊花。用于检测微量组织中BRAF 基因突变的引物组合及其应用。专利号:ZL 2016 1 0423410.6 授权公告日:2019.12.03
22) 唐文如;李珊珊;罗瑛;盛苗苗;王芳;赵月光;张继虹;贾舒婷;吴晓明;刘静;周若宇;旦菊花。用于检测微量组织中PDGFRA基因突变的引物组合及其应用。 专利号:ZL 2016 1 0417813.X 授权公告日:2019.11.08
23)罗瑛;李珊珊;唐文如;盛苗苗;王芳;赵月光;张继虹;贾舒婷;吴晓明;刘静;周若宇;旦菊花。用于检测微量组织中C-KIT基因突变的引物组合及其应用。专利号:ZL 2016 1 0418064.2 授权公告日:2019.11.08
24) 戴文珠;刘宁;毕明瑜;唐文如;罗瑛;盛苗苗。miR-429在制备乳腺癌诊断和检测试剂盒中的应用。专利号:ZL 201710997165.4 授权公告日:2021.03.02