俞飞 副教授 硕士生导师
E-mail:feiyuz8@163.com
教育经历
2010.09-2013.07 北京大学,化学生物学,博士,导师:周德敏 教授
2008.09-2010.07 北京大学,药物化学, 硕士,导师:杨铭 教授
2004.09-2008.07 北京大学,药学专业,本科
工作经历
2016.11-今 公司,威尼斯wns8885556,副教授
2014.03-2016.10 公司,讲师
研究方向
基于天然产物的结构修饰及其广谱抗病毒作用研究
基于基因密码子扩展技术的蛋白药物的非天然氨基酸定点修饰研究
科研基金
(1)国家自然科学基金地区项目(主持,在研):齐墩果酸-葡聚糖多价偶联物广谱抗流感病毒研究,35万元(NO. 22167018,2022-2025);
(2)云南省应用基础研究计划面上项目(主持,在研):齐墩果酸三聚体作为流感病毒进入抑制剂的构效关系及分子机制研究,10万元(NO. 2019FB125,2019-2022);
(3)横向课题(主持,在研):金喉健药效成分抗病毒活性研究及应用,10万元,(2021-2022);
(4)国家自然科学基金地区项目(主持,结题):以齐墩果酸为先导物的流感病毒进入抑制剂研究,42万元(NO. 81560560,2016-2019);
(5)云南省应用基础研究计划面上项目(主持,结题):基于非天然氨基酸及生物正交断裂技术的可控释放性长效干扰素研究,10万元(NO.2018FB145,2018-2021);
(6)云南省应用基础研究计划青年项目(主持,结题):以“病毒进入细胞”为靶的五环三萜抗流感病毒药物研究,6万元(NO. 2015FD012,2015-2018);
(7)云南(昆明)周德敏专家工作站(参与,在研),90万元,(2021-2023);
(8)国家自科基金-联合基金(参与,结题):抗达菲耐药流感病毒活性化合物的发现、结构修饰与作用机理研究,214万元(NO. U1602222,2017-2020)
(9)国家自然科学基金地区项目(主持,参与):三种香薷属植物中三萜类化合物的发现及抗流感病毒活性研究,40万元(NO. 31660100,2017-2020)
(10)国家自然科学基金地区项目(主持,参与):二种雷公藤属药用植物中逆转肿瘤多药耐药性的萜类成分发掘和构效关系研究,38万元(NO. 31660102,2017-2020)
荣誉奖励
(1)呈贡区第三期优秀人才
(2)昆明市科普传播使者
(3)公司大学生创新创业大赛、互联网+大赛优秀指导教师
代表性论文
(1)L Shao; F Yang; Y Su; W Li; J Zhang; H Xu; B Huang; M Sun; Y Mu; Y Zhang; F Yu*. Design and Synthesis of Oleanolic Acid Trimers to Enhance Inhibition of Influenza Virus Entry. ACS Medicinal Chemistry Letters. 2021, 12, 1759-1765
(2)F Yu, M Cai, L Shao, J Zhang. Targeting protein kinases degradation by PROTACs. Frontiers in Chemistry. 2021, 9, 679120.
(3)L Shao, F Yang, W Li, F Yu*. Design, synthesis and anti-influenza A virus evaluation of oleanolic acid C3-glycoconjugates. Chinese Journal of Organic Chemistry. 2021, 41, 2454-2466.
(4)L Meng; Y Su; F Yang; S Xiao; Z Yin; J Liu; J Zhong; D Zhou; F Yu*. Design, synthesis and biological evaluation of amino acids-oleanolic acid conjugates as influenza virus inhibitors. Bioorganic & Medicinal Chemistry. 2019, 27, 115147-115155.
(5)Y Su; L Meng; J Sun; W Li; L Shao; K Chen; D Zhou; F Yang; F Yu*. Design, synthesis of oleanolic acid-saccharide conjugates using click chemistry methodology and study of their anti-influenza activity. European Journal of Medicinal Chemistry. 2019, 182, 111622-111631.
(6)W Li; F Yang; L Meng; J Sun; Y Su; L Shao; D Zhou; F Yu*. Synthesis, structure activity relationship and anti-influenza A virus evaluation of oleanolic acid-linear amino derivatives. Chemical & Pharmaceutical Bulletin. 2019, 67, 1201-1207.
(7)L Shen; F Yu; M Qian; K Zhou; J Liu; Wen Zhang. A [1, 10] phenanthroline derivative inhibits influenza virus propagation through modulating mitogen-activated protein kinase signaling pathways. Nanoscience and Nanotechnology Letters. 2019, 11, 390–397.
(8)L Meng; Q Wang; T Tang; S Xiao; L Zhang; D Zhou; F Yu*. Design, Synthesis and Biological Evaluation of Pentacyclic Triterpene Dimers as HCV Entry Inhibitors. Chinese Journal of Chemistry 2017, 35, 1322-1328.
(9)F Yu; X Zheng; Y Peng; D Zhou; S Xiao. Design and Synthesis of Oleanolic Acid Rings A and C Lactone Derivatives. Chinese Journal of Organic Chemistry 2016, 36, 512-519.
(10)F Yu; Q Wang; H Wang; L Si; J Liu; X Han; S Xiao; L Zhang; D Zhou. Synthesis and biological evaluation of echinocystic acid derivatives as HCV entry inhibitors. Chinese Chemical Letters 2016, 27, 711–713.
(11)H Wang; F Yu; Y Peng; Q Wang; X Han; R Xu; X Zhou; C Wan; Z Fan; P Jiao; Y Zhang; L Zhang; D Zhou; S Xiao. Synthesis and biological evaluation of ring A and/or C expansion and opening echinocystic acid derivatives for anti-HCV entry inhibitors. European Journal of Medicinal Chemistry 2015, 102, 594-599. 共同第一作者
(12)F Yu; Y Peng; Q Wang; Y Shi; S Xiao; C Zhang; M Yu; Y Zheng; L Zhang; D Zhou. Potent Bivalent Pentacyclic Triterpenes as a New Class of HCV Entry Inhibitors. European Journal of Medicinal Chemistry 2014, 77, 258-268.
(13)F Yu; Q Wang; Z Zhang; Y Peng; Y Qiu; Y Shi; Y Zheng; S Xiao; H Wang; X Huang; L Zhu; K Chen; C Zhao; C Zhang; M Yu; D Sun; L Zhang; D Zhou. Development of triterpenes as a new class of HCV entry inhibitors. Journal of Medicinal Chemistry 2013, 56, 4300-4319.
(14)S Xiao; Q Wang; F Yu; Y Peng; M Yang; M Sollogoub; P Sinaÿ; Y Zhang; L Zhang; D Zhou. Conjugation of cyclodextrin with fullerene as a new class of HCV entry inhibitors. Bioorganic & Medicinal Chemistry 2012, 20, 5616-5622. 共同第一作者
(15)F Yu; R Pang; D Yuan; M He; C Zhang; S Chen; M Yang. Design, synthesis, and biological evaluation of novel substituted [1,2,3]triazolo[4,5-d]pyrimidines as HIV-1 Tat-TAR interaction inhibitors. Pure & Applied Chemistry 2010, 82, 339-347.
授权专利
(1)国内发明专利:一类三萜-寡糖偶联物及其应用,授权,发明人:俞飞,孟令宽,杨帆,李唯嘉,苏扬清,邵亮,周德敏;
(2)国内发明专利:一类三萜与直链氨基衍生物的偶联物及其应用,授权,发明人:俞飞,孟令宽,杨帆,苏扬清,李唯嘉,邵亮,周德敏;
(3)国内发明专利:三萜三聚体衍生物及其制备方法与应用,授权,发明人:俞飞,李唯嘉,苏扬清,孟令宽,杨帆,肖苏龙,周德敏;
(4)国内发明专利:一种三萜-氨基酸衍生物、其制备方法和应用,授权,发明人:俞飞,孟令宽,杨帆,李唯嘉,苏扬清,肖苏龙,周德敏。